Collagen Supplementation in Skin and Orthopedic Diseases

Authors: Luana Dias Campos et al.

Release date: March 28, 2023

Journal: Heliyon (Volume 9, Article e14961)

DOI: 10.1016/j.heliyon.2023.e14961

Participants: Hundreds of participants from various studies (literature review)

Duration: 8–48 weeks

Results: Collagen supplements may prevent age-related skin and joint damage

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Effects of Hydrolyzed Collagen Supplementation on Skin Aging

Authors: Roseane B. de Miranda et al

Publication date: 2021

Journal: International Journal of Dermatology

DOI: 10.1111/ijd.15518

Participants: 1,125 participants (95% women, age: 20–70 years)

Duration: 4–16 weeks

Results:

The results of the meta-analysis show that daily intake of hydrolyzed collagen for at least 90 days can improve visible signs of skin aging such as wrinkles, elasticity, and moisture

The effects persisted even after 30 days without supplementation.

Hydrolyzed collagen is an effective and safe method to reduce the signs of skin aging, regardless of the source.

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Dietary Supplementation with Specific Collagen Peptides for Cellulite Morphology

Authors: Michael Schunck et al.

Publication date: 2015

Journal: Journal of Medicinal Food (Volume 18, Pages 1340–1348)

DOI: 10.1089/jmf.2015.0022

Participants: 105 women (age: 24–50 years)

Duration: 6 months

Results: Long-term collagen uptake improves skin morphology.

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Anti-Skin Aging Effects of Collagen Tripeptides and Elastin Peptides

Authors: Shan Lu et al.

Publication date: 2024

Journal: Journal of Dermatologic Science and Cosmetic Technology

DOI: 10.1016/j.jdsct.2024.100019

Participants: 70 women (intervention and placebo groups)

Duration: 9 weeks

Results:

Skin hydration: After 8 weeks, skin hydration in the intervention group increased by 39.19%, while transepidermal water loss decreased by 33.45%

Skin elasticity: Elasticity increased by 25.37%, as measured by the change in skin elasticity values.

Skin collagen: The collagen content in the dermis increased by 21.64%.

Pores, wrinkles and skin texture:

Pore ​​volume decreased by 60%.

The wrinkle length decreased by 18.09%.

Skin roughness was reduced by 15.32%.

Bioavailability: The concentration of bioactive collagen components in the blood increased significantly, indicating good absorption.

Visual improvements: An improvement in skin smoothness and radiance was documented.

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Effects of Oral Collagen for Skin Anti-Aging

Authors: Szu-Yu Pu et al.

Publication date: 2023

Journal: Nutrients (Volume 15, Article 2080)

DOI: 10.3390/nu15092080

Participants: 1,721 patients from 26 studies

Duration: 2–12 weeks

Results :

Skin hydration:

Hydrolyzed collagen (HC) significantly improved skin hydration

The effects were particularly pronounced with longer use (>8 weeks).

Skin elasticity:

Significant improvements in elasticity were observed

Long-term use (>8 weeks) showed stronger effects than short-term use.

Conclusion:

Taking hydrolyzed collagen can improve skin hydration and elasticity, thus positively influencing the skin's aging process

The results underline the importance of longer supplementation (at least 8 weeks) for lasting effects.

The Impact of AP Collagen Peptides (APCPs) on Hair Shaft Elasticity and Gloss: A Comprehensive Analysis

Ahreum Kim, Yujin Kim, Jung Min Lee, Jin-Oh Chung, Jong Hwa Roh, Jung Ok Lee, Beom Joon Kim

Release date: November 9, 2024

Journal: Journal of Functional Foods

DOI (https://doi.org/10.1016/j.jff.2024.106534)

Participants: Ex vivo study on isolated human hair follicles (exact number of samples not specified)

**Duration: Testing period per sample up to 10 days

Results

Hair structure: Increased levels of proline and cysteine, essential for hair elasticity. Improved chemical bond strength, especially disulfide bonds and keratin-associated bonds

Hair surface: Increased lipid levels led to improved shine and smoothness.

Moisture: Increased bound water in the hair cuticle and hair cortex, thereby improving flexibility.

Protein expression: Positive influence on keratin expression.

Conclusion:

APCPs significantly increase hair elasticity and shine through:
improved chemical bonds and lipid composition,
higher moisture levels, and optimized amino acid concentration.

Oral Supplementation with Specific Bioactive Collagen Peptides Improves Nail Growth and Reduces Symptoms of Brittle Nails

Authors: Doris Hexsel et al.

Publication date: 2017

Journal: Journal of Cosmetic Dermatology

DOI: 10.1111/jocd.12393

Participants: 25 women (age: 18–50 years; 24 participants completed the study)

Duration: 24 weeks with a 4-week follow-up period.

Results:

Nail growth rate increased by 12% after 24 weeks and 15% after 4 weeks of follow-up

Reduction in the frequency of brittle nails by 42%

80% of the participants were satisfied or very satisfied with the treatment.

Conclusion:

Daily intake of bioactive collagen peptides improves nail growth, strength, and appearance